Effect Of Christ's Thorn (Ziziphus Spina- Christi) And Tiger Nut (Cyperusesculentus) Fruitson Liver Disorder In Carbon Tetrachloride Induced Hepatic Rats

Khader, Seham; El-Khatib, Basma; El-Sheikh, Yasmine

doi:10.21608/mkas.2017.166197

Effect Of Christ's Thorn (Ziziphus Spina- Christi) And Tiger Nut (Cyperusesculentus) Fruitson Liver Disorder In Carbon Tetrachloride Induced Hepatic Rats

Document Type : Original research articles

Authors

10.21608/mkas.2017.166197

Abstract

This study wasaimed to investigate the effect of Ziziphus spina- Christi and Cyperusesculentusfruits on rats with Liver Disorders. Forty eight white male albino rats, weighing 140-150 g were used in this study. The animals were divided into two main groups. The first main group (n=6) was kept as a control (-ve) group, while rats in the second (n=42) were injected by Carbon Tetrachloride (CCL₄)to induce liver disorder. One of them was kept as a control (+) group and the other six groups treated with different percentages of Christ's Thorn,Tiger Nut fruit and mixture of them(2.5% and 5%) from the basel diet. At the end of experimental period (28 days), rats were fasted over night before slaughtering and blood was collected then centrifuged to separate the serum and estimate liver functions (AST,ALT and ALP) kidney functions (urea, creatinine and uric acid) lipid profile (T.C, T.G and HDL-c) while LDL-c and VLDL-c were calculated and blood analysis (HB ,RBCs ,HCT ,WBCs and PLT). The obtained results revealed that, treated groups by CCL₄ led to significant decrease in body weight gain% , HDL , total protein , Albumin and Globulin and increased AST,ALT and ALP, cholesterol, triglycerides, LDL-c, VLDL-c, uric acid, urea, creatinine. Treating groups which fed on Christ's Thorn, tiger nut fruit and mixture of themshowed significantly (P≤ 0.05) decreased levels of AST,ALT and ALP, Ldl , Vldl , cholesterol, triglycerides , urea, creatinine and uric acidand increase Hdl , total protein , Albumin and Globulin . It could be concluded that Christ's Thornand Tiger Nut fruit were effective inprotecting against hepatic rats not only decreased the level of AST,ALT and ALP but also has beneficial effect on lipids profile and renal profile. Therefore, data recommendas tested Christ's Thornand Tiger Nut by a moderate amount to be included in our daily diets.

Keywords