Effect of Aqueous Licorice (Glycyrrhiza glabra) Extract on Gastric Ulcer Induced by Aspirin in Rats

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The main objective of the present study was to investigate the treatment effect of decoctionaqueous licorice extract (ALE) on peptic ulcer in rats. Twenty eight adult male Albino rats were used in this study. Rats were divided into two main groups. The first group (7 rats) was fed on basil diet as negative control. The second group (21 rats) was given orally aspirin (400 mg/kg) to induce peptic ulcer and divided into three equal subgroups as follow: subgroup 1, fed on basil diet as positive control; subgroup 2, fed on basil diet plus 10% ALE, and subgroup 3, fed on basil diet plus 15% ALE for 28 days. Ulcer index, Curative (%), gastric pH, reduced glutathione (GSH), malondialdehyde (MDA) content  were determined and histopathological parameters were examined. All biochemical investigations referred to treatment efficacy of ALE in treatment groups (3 and 4). Histopathological examination of treatment groups showed that licorice has strong treatment effect on peptic ulcer in both two tested concentrations (10 and 15%).Therfore, the results of this study suggest that licorice can be used for the treatment of peptic ulcer and can protect the stomach against non-steroidal anti-inflammatory drugs induced ulcers.

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