Hypoglycemic Effect of AzollaAlgae (Azollacaroliniana) on Rats Injected by Alloxan

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This study aimed to investigate the effect of Azollacaroliniana on diabetic rats. Twenty five white male albino rats, weighting 150-160 g were used in this study. The animals were divided into two main groups. The first main groups (n=5) was kept as a control (-ve) group, while the second   (n=20) were injected by alloxan to induce diabetes. One of them was kept as a control (+) group and the other three groups treated with different percentages of Azolla algae (1%, 2.5% and 5%) from the basel diet. At the end of experimental period (28 days) rats were fasted over night before sacrificing and blood was collected then centrifuged to separate the serum and estimate serum glucose,liver functions (AST,ALT and ALP) kidney functions (urea, creatinine and uric acid) and lipid profile (T.C, T.G and HDL-c) while LDL-c and VLDL-c were calculated. The obtained results revealed that, treated groups by alloxan led to significant decrease in body weight gain% and increase serum glucose, cholesterol, triglycerides, LDL-c, VLDL-c, uric acid, urea, creatinine, ALP, ALT, AST, and decreased HDL-c. Treating groups which fed on Azollacaroliniana showed significantly (P≤ 0.05) decreased levels of serum glucose, AST, ALT, ALP, urea, creatinine and uric acid. It could be concluded that Azollacarolinianawere effective as protecting against diabetic rats not only decreased the level of serum glucose but also has beneficial effect on lipids profile and liver functions. Therefore, we recommended this tested algae by a moderate amount to be included in our daily diets.

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