Potential Effects Of Colostrums Against Some Biochemical Changes In Diabetic Rats Induced Alloxan

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The present work was concerned with the investigation of colostrums potential effects on some biochemical changes in diabetic rats. The results showed the impact of oral administration of colostrum in diabetic rats.  The biochemical measurements showed an improvement in plasma glucose levels in groups consumed cow colostrum (5&10 ml\kg bw). The decrement was reach 30.80% and 20.40%. On the other hand there were highly significant increases in serum total proteins, albumin and globulin in diabetic rat groups consumed colostrums compared to their corresponding control group. Cow colostrum has positive effect on reducing both urea and creatinine in groups consumed colostrum.
While diabetic rats consumed colostrums levels at (5&10 ml\kg bw) it resulted in significant reduction in lipids pattern, total cholesterol, triacylglycerol, LDL-c and superoxide dismutase in association with the increase in HDL-c, malondialdehyde and  glutathione compared to their corresponding control group. In summary, the results of this study indicated that some of the abnormalities that accompany the development of diabetes mellitus in rats given alloxan are ameliorated and improved metabolic parameters by dietary cow colostrum intake.

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