Effect of Flaxseed, Sesame Oil and their Mixture on Liver Dysfunction of Albino Rats

The present study aimed to evaluate the effect of flaxseed, sesame oil and their mixture on carbon tetrachloride-induced liver dysfunction in albino rats. Thirty (30) Sprague-Dawley white male albino rats, each weighing 140 ±5 g, were housed in group cages under conditions and fed on basal diet for adaptationfor at least seven days before experiments. The rats were divided into five main groups (6 rats each) as follows: Group (1) Negative or normal group (-Ve): Fed on basal diet only. The other rats were injected by Ccl₄ then divided into four groups as follow: Group (2) Positive group (+Ve): Fed on basal diet only. Group (3): Fed on basal diet plus 5% of flaxseed oil. Group (4): Fed on basal diet plus 5% of sesame oil. Group (5): Fed on basal diet plus 5% ofequalized mixture of flaxseed and sesame oil.The results revealed that liver dysfunction reduced FI, BWG, FER and serum HDL-c. On the other hand raised serum TC, TG, VLDL-c, LDL-c, AI, glucose, AST, ALT, ALP, urea, creatinine, uric acid levels and kidney weight. Feeding on diets containing flaxseed oil, sesame oil and their mixture at 5% level reversed such changes, sometimes to better level as compared to control (+Ve) group, provided that the best treatment was found for the mix diet indicating the synergistic action and mostly sesame oil revealed relatively better improvement of liver and renal functions. Feeding on diets containing flaxseed oil, sesame oil and their mixture at 5% level revealed normal structure of liver section exactly as in case of control (–Ve) group.
Conclusion: In conclusion, feeding on diets containing flaxseed, sesame oil and their mixture improved the biological and biochemical parameters of liver dysfunction rats, provided that best results obtained with their mixture diet.