Exploration The Hepatoprotective Activity Of Lemon Balm Leaves (Melissa Officinalis L.) In A Rat Model Of Oxytetracycline-Induced Fatty Liver

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With growing burden of liver dysfunction, using natural plant products is increasing because of their attributes of sturdy antioxidant contents, negligible side effects and economical features.  Thirty two rats weighing 120-130 g were haphazardly divided into four groups (n=8). Oral administration of oxytetracycline (120 mg/kg body weight/day) for three days produced hepatic damage as manifested by a significant elevation in serum hepatic markers namely aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transferse (GGT) and lactate dehydrogenase (LDH), also increased hepatic lipid peroxidation (MDA). The oral administration of lemon balm (10 and 20 g/kg body weight) attenuated the oxytetracycline induced hepatotoxicity by significantly (p≤0.05) reducing levels of serum AST, ALT, GGT, LDH, glucose, TG, TC, LDL-C, urea, creatininie and malondialdehyde (MDA) and significantly (p≤0.05) increased in serum total protein, albumin, globulin, HDL-C in lemon balm treated rats comparing with untreated fatty liver group. As well as increase in superoxide dismutase (SOD) and total antioxidant capacity in lemon balm treated groups especially the dose of 10 g comparing with untreated fatty liver rats. In conclusion, lemon balm treatment had remarkable effects on hepatic biomarker enzymes level and lipid peroxidation in rats. It is stipulated that administration of lemon balm leaves to treated groups were partially protected from hepatocellular damage caused by oxytetracycline

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