AdministrationofFicusCarica L Fruit andCoenzyme Q10 Attenuate Potassium Bromide Induced Oxidative Stress inRats

Figs fruit are considered good source of important bioactive constituents like phenolics and antioxidants. No systematic study has been done on protective efficacy of Ficuscarica L (dried & juice) with coenzyme Q10 to treat oxidative stress caused by potassium bromide in rats, so it were investigated.
Fifty six albino rats divided into seven groups (n=8) for a six-weeks experimental period; group (1) normal control, group (2) KBrO3-intoxicated control, groups (3) treated with 15 % figs powder (FP) in diet, groups (4) administrated 150 mg/kg bwt figs Juice (FJ) by gastric tube and groups (5-7) treated with Q10 (15 mg/kg bwt), FP+Q10 (50/50) and AJ+Q10 (50/50).
Total phenolics was 60.23 expressed as gallic acid equivalent /100g dry matter, flavonoid content was 116.3 mg∕100g and total antioxidant activity as ferric reducing antioxidant power (FRAP) was 6.3 Fe2+ mmol/kg, those phytochemical characters and antioxidant capacity may responsible for potential health-promoting effects of figs.
Significant antioxidative stress effects were reported against KBrO3 (200 mg/kg bwt. in drinking water along experimental period) as evident from decreased levels of serum kidney function biomarkers (creatinine, urea and uric acid), serum lipid biomarkers (CHO, TG, LDLc and VLDLc) also MDA levels in groups administrated figs powder and juice separately or with Q10 compared to the intoxicated control group. Administration of (FP) and (FJ) separately or with Q10 and Q10 also improves nutritional results, increases serum and kidney antioxidant enzymes and elevates the value of HDLc compared to intoxicated control.
Best results revealed that administration of (FP) or (FJ) with Q10 due to synergistic effects could afford significant dose-dependent protection against KBrO3 inducing oxidative stress.
   It is concluded that (FP) and (FJ) with and without Q10 has beneficial effects on growth performance, renal function and lower oxidative stress induced by KBrO3 because of its phytochemical components and antioxidant effect.