The effect of aqueous extract of stevia (Stevia rebaudiana Bertoni), as a natural sweetener, on lowering blood glucose and serum lipid profile in hepatotoxic diabetic rats induced by alloxan (150 mg/ kg body weight) and Ccl4 (2ml / kg body weight). Twenty four male rats, weighing 190±20g were divided into 4 groups as follows negative control (normal) and three hepatotoxic diabetic rat groups, 1st group, positive control (hepatotoxic diabetic , untreated), 2nd and 3rd groups (hepatotoxic diabetic animals) were given stevia extract and aspartame orally for 6 weeks at a daily dose of 400 mg/kg body weight. The results indicated that treatments with stevia extract and aspartame significantly (P≤0.05) decreased the levels of blood glucose, total cholesterol (TC), Triglycerides (TG), low density lipoprotein cholesterol (LDL-c) and very low density lipoprotein cholesterol (VLDL-c) as compared with positive control rats. Stevia extract was more effective (P≤0.05) in reducing serum TC, TG, LDL-c and VLDL-c than aspartame. On the other hand stevia extract significantly (P≤0.05) improved high density lipoprotein cholesterol (HDL-c) compared with positive control. Treatments with stevia extract significantly (P≤0.05) increased glutathione- S- transferase (GST) and catalase CAT and significantly (P≤0.05) decresed malondialdehyde (MDA) compared to control (+) group, while, there was no significant difference of CAT among positive and aspartame group.Oral administration of stevia extract and aspartame significantly (P≤0.05) decreased Alanine aminotransferase (ALT), Gamma-Glutamyl Transferase (GGT) and Alkaline phosphatase (ALP) as compared with positive control rats. Oral administration of aspartame cased a significant (P≤0.05) increased in aspartate aminotransferase (AST) compared to positive group. Stevia extract was more effective (P≤0.05) in reducing serum AST, ALT, GGT and ALP than aspartame. In conclusion, this study indicated that stevia aqueous extract, as a natural sweetener, had hypoglycemic, hypolipidaemic effects as well as improved the antioxidant status of hepatotoxic diabetic rats.
alsemary, A., youssif, H., abd-elaziz, A., & al-beltagy, A. E. (2015). Potential Therapeutic Effects Of Stevia Extract On Hepatotoxic Diabetic Rats. Journal of Home Economics - Menofia University, 25(1), 61-82. doi: 10.21608/mkas.2015.165424
MLA
ayat alsemary; heba youssif; abeer abd-elaziz; alaa el-din al-beltagy. "Potential Therapeutic Effects Of Stevia Extract On Hepatotoxic Diabetic Rats". Journal of Home Economics - Menofia University, 25, 1, 2015, 61-82. doi: 10.21608/mkas.2015.165424
HARVARD
alsemary, A., youssif, H., abd-elaziz, A., al-beltagy, A. E. (2015). 'Potential Therapeutic Effects Of Stevia Extract On Hepatotoxic Diabetic Rats', Journal of Home Economics - Menofia University, 25(1), pp. 61-82. doi: 10.21608/mkas.2015.165424
VANCOUVER
alsemary, A., youssif, H., abd-elaziz, A., al-beltagy, A. E. Potential Therapeutic Effects Of Stevia Extract On Hepatotoxic Diabetic Rats. Journal of Home Economics - Menofia University, 2015; 25(1): 61-82. doi: 10.21608/mkas.2015.165424
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