Slimming of Obese Sprague Dawley   Male Albino Rats by Garcinia Fruit  as Enhanced with Citrus Fruit Peels

Ragab, Sherif; EL-Dashloty, Mohamed; EL-Sherif, Fatma; Gouda, Lamis

doi:10.21608/mkas.2018.165106

Slimming of Obese Sprague Dawley Male Albino Rats by Garcinia Fruit as Enhanced with Citrus Fruit Peels

Document Type : Original research articles

Authors

10.21608/mkas.2018.165106

Abstract

The effects of Garcinia fruit , Garcinia fruit with lemon peels 5% & 7.5%, orange peels 5%& 7.5% , and grapefruit peels 5%& 7.5% powders on some biological, biochemical and histological factors of obese rats were studied. Fifty five adult male rats were distributed into eleven groups, the eleven groups were fed on high fat diet for induction of obesity. One of these groups was kept as positive control while the left nine groups were given daily garcinia fruit 5%&7.5%, garcinia fruit with lemon peels 5%& 7.5%, orange peels 5%& 7.5% , and grapefruit peels 5%& 7.5%, for 28 days. Results showed that body weight gain was markedly lower especially in the fruit powder at the level 7.5% compared to high fat diet control group. Non significant difference reveled of among group 3-11. Administration of fruits and peels at 5% and 7.5% lowered concentrations of total cholesterol, triglycerides, LDL-c, VLDL-c and decreased activity of AST , ALT and ALP enzymes and lowered creatinine, urea and uric acid of serum while HDL-c concentrations were significant increased . Histopathological examination showed amelioration of histopathological lesions seen in liver and kidney of obese rats when received the garcinia and citrus peels. So, this study concluded that intake of garcinia and citrus peels at 5%,7.5% can be useful for coping obesity.

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