Effect Of Ethanolic Extract Of Psidium Guajava And Moringa Oleifera Leaves On Acute Renal Injury In Experimental Rats

 This study was carried out to investigate the effect of ethanolic extracts of  Psidium guajava and  Moringa oleifera leaves  on acute renal injury in experimental rats.  Thirty albino rats weighing 200 ± 20 g used in this study and  divided into two main groups, one wasthe first main group ( 5 rats )  who  kept as a control –ve group, while another was the second main group ( 25 rats ) , was injected intraperitoneally( IP) with a single dose of  cisplatin (CP) (7ml / kg B.Wt.) to induce acute renal
 injury. After induction,  the rats in the second main group were divided into five groups (each group consisted of 5 rats) ,  one group was kept as  (+ ve) control group, while others  given administration of  ethanolic extract of  Psidium guajava leaves ( EEPGL) and ethanolic extract of  Moringa oleifera leaves (  EEMOL) ( 100 and 200 mg/kg)] orally  for six weeks.  Biological evaluation including feed intake (FI), body weight gain % (BWG %)  and feed efficiency ratio (FER) were carried out. Serum creatinine, Serum urea and serum uric acid were measured. Antioxidant levels in kidneys tissues  (Super  Oxide Dismutase  (SOD) , Glutathione Peroxidase ( GPX ) , Catalase ( CAT), Malondialdehyde ( MDA)  and  Nitric oxide( No)  were estimated. Blood glucose was determined .  Also, histopathological changes for kidney, were examined. The obtained results concluded that using  EEPGL and EEMOL  improve  FI, BWG % and FER, Serum creatinine, Serum urea and Serum uric acid,    antioxidant enzymes and blood glucose level. The best results found by using high doses  ( 200mg / kg) of EEPGL and EEMOL  . According to the results, EEPGL and EEMOL  could be used for improving kidney functions and curing acute renal injury .