Influence Of Moringa Oleifera Seeds Oil In Liver Protection And Blood Lipid Reduction In Diabetic Rats

The present study has been conducted to estimate the influence of Moringa oleifera seeds oil in protection the liver and reduction of blood lipids in diabetic rats. Forty male rats were divided into four groups. Non-diabetic rats fed standard diet only (G1), non-diabetic rats fed standard diet + Moringa seeds oil (1.8 mg/kg) (G2), diabetic rats fed standard diet (G3) and diabetic rats fed standard diet + Moringa seeds oil (1.8 mg/kg) (G4).The study conducted for four weeks. The results showed that liver weight and relative liver weight were significantly increased in diabetic rats (G3) compared with (G1) and significantly decreased in diabetic rats treated with Moringa seeds oil (G4) compared with (G3). Treatment diabetic rats with Moringa seeds oil (G4) showed significantly reduction in serum glucose level comparing with non-treated diabetic rats (G3).The diabetic rats (G3) showed significantly elevation in levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), low-density lipoprotein (LDL), total cholesterol(CHOL) and significant decreased in high-density lipoprotein (HDL) compared with (G1). Diabetic rats treated with Moringa seeds oil (G4) showed a significant reduction in liver enzyme markers and improved in lipid profile parameters compared to non-treated diabetic rats (G3).The study concluded that Moringa seeds oil can be protect the liver and reduce blood lipids in diabetes. The potential mechanism of Moringa seeds oil in protection the liver possibly resulting from ability of free radical scavenging by antioxidants in the oil.