Potential Effect of Kiwifruits and Their Extract on Side Effects in Obese Rats

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The present investigation aimed to study the effect of supplementation kiwifruit and their extracts on obese albino rats. Thirty six male Sprague Dawley rats were divided into two main groups. The first main group (6 rats) was fed on basal diet as a (control negative group-ve) (group1) , while the second main group (30 rats) was fed on high fat diet for six weeks. The second main group was divided into five groups (6 rats each). Group (2) was fed on high fat diet (control positive group +ve). Groups (3-6) fed on high fat diet containing 5% kiwi, 10% kiwi; kiwi extract 100mg/kg and 200mg/kg, respectively. At the end of the experimental period (8weeks) rats were fasted over- night before sacrificing, blood was collected then centrifuged to separate the serum. Results revealed that, feeding rats on high fat diet led to significant increase in serum glucose, cholesterol, triglycerides, LDL-c, VLDL-c, urea nitrogen, creatinine and decreased HDL-c. As conclusion, obese rats treated with 200 mg/kg kiwifruit extract had improved the lipid profile, liver and kidney functions compared with kiwi fruit as powder.
 

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