Study The Effect Of Chicory (Cichorium Intybus, L.) Leaves Powder On Some Biochemical And Biological Parameters Of Hepatotoxicity Induced By Ccl4 In Rats

The present study aimed to assess the effect of different concentrations (2.5 , 5  and 10 %) of  Chicory (Cichorium intybus) leaves powder (Ch.L.P.) on impaired liver function of injected rats with Carbon Tetrachloride (CCl4,. Twenty five mature albino male rats weighing (140±10g)  were randomly divided into five groups (n=5) and fed on the basal diet. The first group: negative control and the other four groups  were injected by Carbon Tetrachloride (CCl4) in paraffin oil 50% V/V (2ml/Kg. B.W) twice in a week for two weeks to induce hepatotoxicity. The second group ( positive control) the third, fourth and fifth groups were fed on the basal diet containing 2.5%, 5% and 10% of Chicory leaves powder respectively for 28 days. Serum liver enzymes, lipid profile, total protein, albumin, glucose, antioxidant liver enzymes (SOD, GPX and CAT)  and hestopathological changes of liver tissues were examined and investigated, Also, phenolic compounds profile of (Ch.L.P.) was determined by HPLC. Obtain results of CCl4 treated rats compared to control (+ve) groups revealed that rats fed on 10 % (Ch.L.P.)recorded the significant lowest glucose level (p≤0.05).   Antioxidant liver enzymes (SOD, GPX and CAT), were increased siginificantly in all treatment fed on ChLP . The significant  increase  in albumin and total protein in 10% fed group .Total serum biliruben recoded the lowest significant in 10% group. For serum liver enzymes (ALT, AST  and ALP);  the lowest significant values were noticed in 10% fed group . Lowest significant level  of triglyceride and cholesterol were recorded in groups fed on 10% ChLP. The highest significant level of HDL-c was recorded for group fed on 10% ChLP. While, The lowest significant value of  LDL-c and VLDL-c was recorded for rats fed on 10% ChLP .
In conclusion,  chicory plant leaves could be considered as powerful nutraceutical therapeutic agent for the treatment of hepatotoxicity induced by CCl4 in rats. All used concentrations in this study cause improvment in  hepatotoxicity rats.