Possible Effects of mango, avocado seeds and their mixture in Alloxan-Induced Diabetic Rats

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The present study was designed to study the effect of mango, avocado seeds and their mixture on diabetic rats. Forty adult male albino rats were used in this study, weighting (150±10g) were divided into eight groups, five rats each. Avocado, mango seedsand their mixture as powder were added at percent 2.5 % and 5% from the main diet. Rats induced alloxan at dose of 150 mg/kg to infect diabetes. Serum lipid profiles (TG, TC, LDL-c, VLDL-c, HDL-c), serum glucose, serum liver enzymes activities (GOT and GPT), kidney function (creatinine, uric acid and urea levels) were also determined. From the obtained results it could be concluded that feeding onmango, avocado seeds and their mixtureas powder caused significant (P ≤ 0.05) increase in HDL-c, compared with control (-ve) group, and enhanced the kidney and liver functions with the decrease of ALT, AST, ALP, serum glucose, creatinine, uric acid, urea which reflects the powerful nutraceutical therapeutic effect for feeding onmango, avocado seeds and their mixtureas a powder for treatment diabetic in rats.The best result was to concentrate 5% mixture of mango and avocado powder.
 

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