Relative Effects Of Chicory, Sonchus As Well As Leek And Celery Varieties On Paracetamol Hepatopathy And Immunity Of Rats

Abstract: The present work aimed to evaluate the effect of chicory, sonchus,Egyptian leek, Chinese leek, Egyptian celery and Chinese celery (as 5%) on paracetamol intoxicated and immunity of rats. For this purpose, the studies included 40 rats about 150/100(g) weight. Rats were fed on normal (basal) diet for one week. The animals were divided to 8 equal groups; one was kept as control- ve group, while the other 7 groups were treated orally by paracetamol (500 mg / kg.B.Wt.) for 5 days to induce hepatotoxicity. Group (2): Control positive (+ve), in which hepatotoxicity rats were given orallyparacetamol then were fed on basal diet for 28 days. Group (3): Paracetamol hepatotoxicity rats were fed on basal diet containing 5 % chicory for 28 days. Group (4): Paracetamol hepatotoxicity rats were fed on basal diet containing 5% sonchus for 28 days. Group (5): Paracetamol hepatotoxicity rats were fed on basal diet containing 5% Egyptian leek for 28 days. Group (6): Paracetamol hepatotoxicity rats were fed on basal diet containing 5% Chinese leek for 28 days. Group (7): Paracetamol hepatotoxicity rats were fed on basal diet containing 5%   Egyptian celery for 28 days. Group (8): Paracetamol hepatotoxicity rats were fed on basal diet containing 5%   Chinese celery for 28 days. At the end of experimental period (28 day), animals were sacrificed. Blood samples were collected to determine the following parameters: Antioxidant enzymes (SOD,CAT and GPx), level of serum liver enzymes (ALT, AST and ALP), total cholesterol, triglycerides, lipoprotein fractions (HDL-c&LDL-c). Complete blood count including immunity cells count (WBC, Lymph, NEUTROPHILS, and MONO) were assessed. BWG calculated, liverand kidney were weighted then kept in (10%) formalin solution for histopathological examination.The results revealedthat due to hepatointoxication, rats BWG was decreased. Feeding on basal diet contained chicory, sonchus,Egyptian leek, Chinese leek, Egyptian celery & Chinese celery (as5%) raised the BWG. Inflicting with paracetamol raised the internal organs weights while the reverse indicated on feeding with chicory, sonchus,Egyptian leek, Chinese leek, Egyptian celery & Chinese celery (as5%). Paracetamol hepatotoxicity rats showed an increase of TC, TG& LDL,but decreased the serum HDL. Inflicting rats with paracetamolhepatotoxicity raised the activities of serum GOT, GPT   and ALP. When feeding with chicory, sonchus,Egyptian leek, Chinese leek, Egyptian celery & Chinese celery (as5%) these levels were reduced. There were a significant decreases in SOD, GPx and CAT in the blood of rats poisoned by paracetamol, while given orally rats with paracetamol then fed on these plants revealed a significant increases when compared with (C +ve) group. Paracetamol hepatotoxicity rats decreased WBC&Lymph, but increased NEUTROPHILS &MONO. Accordingly rats immunity raised due to feeding treatments of present work.