Protective Effect of Grapes of Beer Seeds and Hops Leaves as Powder in Treatment of Kidney Functions on Nephrotoxic Rats

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This study was conducted to investigate the protective effect of different concentrations (2.5% and 5%) of grapes of beer (Arctostaphylos uva-ursi)seedsand hops (Humulslupulus) leaves and their mixture as powder on nephrotoxic rats. Forty eight white male albino rats, weighing 150±10g were used in this study. The rats were divided into 8 groups, (n=6 rats).
One was kept as a control negative group while the other groups were injected by gentamicin (10 mg/kg body weight) once day for 10 days. Glucose level, serum liver functions (ALT, AST and ALP), kidney function markers (urea, uric acid and creatinine), total cholesterol, triglycerides, and lipid profile (HDL-c, LDL-c and VIDL-c) were determined. The obtained results revealed that grapes of beers seeds and hops leaves powder and their mixture improved liver functions, kidney functions, serum glucose levels, and lipid profile in rats. The best results recorded for 5% mixture and recommended for used as a beverage drink to improve kidney functions. Also hops diet alone, seems to be of better action compered to grapes of bear diet alone.

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