Potential Therapeutic Applications of Persimmon (Diospyros kaki-Virginiana) fruits and leaves as Evaluated on diabetic Male Albino Rats

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This study aims to study  the effects of Persimmon (Diospyros kaki-Virginiana) fruitsand  leaves on biological and  biochemical parameters  of diabetic   rats.  Forty male mature albino rats weighing 140-150g per each, were randomly divided into two main groups .Group І: negative control (-ve) fed on standard diet . Group П: diabetic rats n=35 (treated by alloxan 150 mg\kg Bwt. to induce diabetic) ,  then  divided into equal seven subgroups  the first : group was  kept as control (+ve) , while the left  six groups were given daily fruits and  leaves of Persimmon (Diospyros kaki-Virginiana) powder at 2.5% , 5% and 7.5%  for 28 days. At the end of the experiment, Body weight gain (BWG), Feed intake (F.I), Feed Efficiency Ration(FER),  glucose , Serum asparatate aminotransferase (AST) ,Total protein, serum albumin, Globulin, Serum alanine aminotransferase (ALT) , Alkaline phosphatase (ALP) , urea, creatinin, uric acid were determined . The results of the obtained data showed  that BWG , FI and FER were  markedly  non significant in all tested groups as compared to control (+ve) group. Also, data  indicated that  the effect of persimmon  leaves was higher than the effect of persimmon fruit on blood glucose and feeding on 7.5% persimmon leaves had the highest effect. Incase of total protein all diabetic rats fed on different diets showed significant increases in mean values as compared to control (+) group. The best treatment considering the serum  total protein (T.P) was recorded for group"8" (7.5% persimmon leaves ) in comparison with control (-) group.   Also, serum albumin increased  rats which fed on groups 4, 6 and 8 (diabetic rats fed on 2.5% persimmon leaves , 5% persimmon leaves and 7.5% persimmon leaves  , respectively ) showed nonsignificant differences between them and  there  were non significant as compared to control (-) group. So, the best results of ALB were recorded in these groups . beside that  , all diabetic rats fed on various diets revealed a significant decreases in mean values as compared to control (+) group for serum globulin mean . while, improved liver and kidney functions. So, from this study results  concluded  that intake of fruits and leaves powder of  persimmon fruit especially at  7.5% can be useful for  improving diabetic 

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