Effect of germinated chickpea flour on bone healthofovariectomized ratsas model of menopause

Document Type : Original research articles

Authors

Abstract

Menopause affects a woman on all levels, from organs to bio-mentalpsycho-social functioning. Postmenopausal osteoporosisis a common disease related by the decrease of bone mass and bone structure changes, usually attributed to estrogen deficiency. The present study aimed to assess the effect of germinated chickpea flour on ovariectomized (ovx) rats (as model of menopause).The study was performed on thirty five adult female albino rats. They were divided into five equal groups. The first group was sham operated (7 rats) and the other four groups(7 rats each) were ovariectomized. The sham group (negative control) and one ovx group (positive control) were fed basal diet, whereas the remaining three ovx groups were fed basal diet containing 2.5, 5 and 7.5% of germinated chickpea flour. Supplementation rats diet with germinated chickpea flour led to the improvement of serum calcium, ionized calcium, phosphorus, magnesium, alkaline phosphatase activity, bone-specific alkaline phosphatase activity, osteocalcin, calcitonin, parathyroid hormone and lipid levels compared to positive control group. Also calcium, phosphorus, magnesium and BMD in femur and tibia in ovx groups supplemented with different concentration of germinated chickpea flour were significantly higher than in the positive control group. However, no significant differences were observed in estrogen level, femur and tibia weights and lengths between positive control and ovx groups supplemented with 2.5% of germinated chickpea flour. These results suggest that germinated chickpea flour is effective in improving lipid levels and bone health in ovariectomized rats.

Keywords

Main Subjects

Files

Share

How to cite

Statistics