Potential protective effects of Artichoke plant on peptic ulcer in rats

:    Artichoke has been reported to be used internally for the treatment of inflammation of the intestinal mucosa.  It has been claimed to act as an antioxidant. The objective of this  study  was added artichoke powder in baked products  and its assessed  the protective activity  of  artichoke against  peptic  ulcer which  induced  by  ethyl alcohol in adult male rats. Artichoke was used to replace part of the whole wheat flour ( 2.5%, 5% and 10%) in standard cake.  Appearance, taste, flavor, texture, color and overall acceptability  were evaluated in cake .The results showed that groups which  treatment with artichoke were significantly decreased in ulcer score,   ulcer index and increase in preventive index compared with the    positive control group. Supplemented rats diet with 10% of artichoke powder were more effective to protect the stomach   of ulcer. Moreover sensory evaluation showed that all replacement of artichoke in cake were showed acceptable by the panelists. It concluded that artichoke had a protective activity against peptic ulcer in adult rats which induced by ethyl alcohol.  Also, Thirty rats were  randomly  divided  into  five  groups (n=6  for  each),  the  first  and second  groups  fed  standard  diet, from the third to the fifth groups fed standard diet containing 2.5, 5, 10% artichoke powder(AP). The rats of second to fifth groups were received a single orally dose of ethyl alcohol 90% at 10 ml/kg body weight. After two hour later and under anesthesia by diethyl ether,  abdominal wall was opened, the pylorus identified, stomachs ligated  from esophageal opening, removed, opened at greater curvature,  gastric juice collected and centrifuged for studying of gastric secretion  parameters.