The Relationship between Sodium Nitrate and Potassium Bromate Consumption and Hepatotoxicity in Rats

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The present study aims to discoverthe oxidative damage and changes in liver enzymes activities that may be occur of sodium nitrate, potassium bromate administration. Male rats were divided into four equal groups. Group 1 used as control, group 2, 3 and 4 treated with sodium nitrate (500 mg/L), potassium bromate (400mg/L) and their mixture (500mg sodium nitrate plus 400mg potassium bromate), respectively. The activities antioxidant enzymes, thiobarbituric acid-reactive substances (TBARS), glutathione, liver and plasma enzymes were determined. The results showed that treatment with sodium nitrate and potassium bromate resulted in significant (p≤0.05) decrease in antioxidant enzymes activities and glutathione level,while, the level of TBARS significantly (p≤0.05) increased than control group. Also, treatment with sodium nitrate and potassium bromate caused significant (p≤0.05) increase in plasma lactate dehydrogenase (LDH), acid phosphatase (ACP), alkaline phosphatase (ALP), alanine transaminase (ALT) and aspartate transaminase (AST) while, all these enzymes were significantly (p≤0.05) decreased in liver. Treatment with sodium nitrate plus potassium bromate in the mixture group caused significant (p≤0.05) changes in these parameters compared to treated animals with either sodium nitrate or potassium bromate alone. In conclusion, the use of sodium nitrate and potassium bromate should be limited because they have negative effects on health, causing adverse changes in antioxidant enzymes activities and liver enzymes.

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