Effects of Probiotics and Prebiotics Dietary Supplementations on Some Parameters of Diabetic Rats

Document Type : Original research articles

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Currently dietary interventions become very critical widelyso it has been recommended for many diseases. e.g., patients with diabetes mellitus(DM), heart diseases, obesity, stroke and cancers should consume foods rich in flavonoid compounds in order to improve their health states. The current study carried out to investigate the effects of different levels of dietary Arabic Gum (AG)supplemented with Yogurt (Y) on diabetic health states using animal models. Thirty male rats were used and divided into six groups; the 1st is the control healthy group (1) that fed on basal diet while the rest of all the groups were diabetic induced and one of them used as control positive group (2). Additionally, groups 3 &4 were fed basal diets supplemented with 5 % of either Y or AG each separately while group 5 was fed 5 % of mixed Y and AG on their diets. Body weight, blood glucose levels in addition to liver functions and pancreatic histopathology were evaluated after consuming the supplemented diets. Collected data showed that glucose levels were significantly decreased (P<0.05) after AG and Y consumptions. However, the highest effect has been seen with 5% concentration. Also, ALT and AST that were determined as liver functionswere significantly decreased (P<0.05) after AG consumption comparing to the positive diabetic group and the other tested groups. In conclusion, the obtained results suggested that AG is highly recommended with to be used as dietary medication especially at the level 5% for diabetic and hyperlipidemia patients. However, further human studies are needed.

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