Hepatoprotective Effect Of Calendula Officinalis Flowers On Ccl4 Induced Rats.

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This study was carried out to evaluate the hepatoprotective Potential of Calendula officinalis flowersagainst aflatoxins induced liver damage. On impaired liver function of rats injected with Carbon Tetrachloride (CCl4). Thirty-six male mature albino rats weighting 150-160g per each were used in this study and divided into 6 equal groups, the first group was kept as a control (–ve) group, the second group(+ve) which rats inflicted with hepatotoxicity by CCl4 were fed on basal diet . The tested plant powder flower was given to the rats as a percent of C.officinalis 1, 2.5, 5, and 7.5% from the Basel diet for 28 days. At the end of the experimental the serum liver functions (GOT, GPT, ALP), kidney functions (Urea, Creatinine and Uric Acid), F.I, F.E.R, B.W.G%, High-density lipoprotein (HDL-c), Total Cholesterol (T.C) and Triglycerides (T.G)of rats and histopathological changes of liver were examined. The results of the obtained data indicated that tested plant significantly (P≤0.05) decreased serum, TG, TC, and increased HDL. Also, the tested plants improved liver and kidney functions.

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