Evaluation of Effect of Omega -3 Fatty Acids And Probiotics In Rats With Nonalcoholic Fatty Liver Disease (NAFLD) Induced By Special Diet

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Nonalcoholic fatty liver disease (NAFLD) is defined as the excessive accumulation of triglycerides in ≥5% of hepatocytes in the absence of significant alcohol consumption. This study aimed to investigate the dietary protective effect of omega-3 and probiotics on liver fatness and functions after induction of fatty liver in rats through feeding high fructose diet. This study included thirty (30) adult male Wister albino rats weighing140±10, they were divided in to 5 groups: Group (1) included control negative rats, Group (2) included control positive rats, Group (3) included diseased rats treated with omega 3, Group (4) included diseased rats treated with probiotics, Group (5) included diseased rats treated with both omega 3 and probiotics. The results showed  the  highest improvement in lipid profile, liver functions and liver histopathology in group treated with both omega 3 and probiotics followed by group treated with probiotics and finally followed by group treated with omega 3 with a slight variations between group treated with probiotics and group treated with omega 3. From the previous results it can conclude that co-administration of omega-3 fatty acids and probiotics daily for 4 weeks to rats with NAFLD can significantly reduce liver fat, improve serum lipids, metabolic profile, and reduce pathological changes in fatty liver.

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