Protective Effect of Fig, Sycamore and their Mixture on Kidney Disorder in Gentamicin-Induced Rats

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The protective effect of different concentrations 2.5 and 5 % of fig (Ficus carica, L.), sycamore (Ficus sycomorus, L.) and their mixture as powder on gentamicin-induced nephrotoxicity and to elucidate the potential mechanism male rats was investigation. Forty eight male albino rats weighing 150±10 g were used, and divided into 8 equal groups, first one was kept as a negative (-ve) control group, while the other 7 groups were injected by gentamicin at the dose of 10mg/kg body weight for 10 consecutive days. The obtained results concluded that the best treatment of urea, uric acid and creatinine was recorded for rats fed on 5% mixture fruits as compared to positive control group. The lowest liver enzymes (ALP, ALT and AST) recorded for group fed on 5% mixture fruits as powder as compared to positive control group. All nephrotoxic rats fed on different diets revealed significant decreases in total cholesterol, triglyceride LDL-c and VLDL-c with the mean values as compared to positive control group. While, all nephrotoxic rats fed on different diets revealed significant increase in HDL-c with the mean values as compared to positive control group. As conclusion, the rats fed with mixture fig and sycamore as powder improving the kidney functions, liver functions and lipid profile.

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