Potential Effect of Broccoli to Reduce the Side Effects of Cisplatin Chemotherapy in Adult Rats

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Multidrug resistance and various adverse side effects have long been major problems in cancer chemotherapy. The discovery of bioactive components in foods is exciting, suggesting the possibility of improved public health through diet. Broccoli floret are an excellent source of health-promoting phytochemicals such as vitamins, glucosinolates, and phenolics. The present study aimed to examine the therapeutic effects broccoli powder to reduce the side effects of cisplatin chemotherapy in adult rats. Twenty four adult male albino rats were randomly divided into two main groups; the first main group served as a negative control and the second main group (18 rats( were injected with a single intraperitoneal dose of cisplatin  (CP) (10 mg/kg of B.W.). This group were divided into three subgroups, subgroup 1 served as positive control group, subgroup 2 and 3 were fed on the diet containing 2.5% and 5% broccoli powder.  After completing the treatment period, animals were sacrificed under diethyl ether anesthesia. Blood samples were collected for the biochemical analysis. Results showed that group rats fed on 5% broccoli floret recorded the highest effective to reduce SGPT, SGOT, ALP, T.P, TC and TG level compared with group rats fed on 2.5% broccoli floret. Also, 5% broccoli improvement all tested oxidative enzyme (SOD, NAD and CAT) was observed. In conclusion, group rats fed on 5% broccoli floret markedly the side effects of cancer patients treated with cisplatin.

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