Comparison Study between Antioxidants Therapy and Diet Therapy in Non-Alcoholic Fatty Liver Patients

Document Type : Original research articles

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Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that can progress to cirrhosis. Vitamin E and C can be used in its treatment owing to their antioxidant effects. Prescriptive diet therapy also seems to have a promising effect in Nonalcoholic fatty liver disease (NAFLD) management.
Aim of the work: This study aims to investigate that the effect of therapeutic diets with some natural foods rich in Vitamin C and E on non-alcoholic fatty liver disease.
Subject and methods: This cross-sectional study including 90 patients who were divided into three groups (30 in each). The first group (nutritional therapy group) received nutritional therapy according Individualized nutritional therapy only, the second group (Vitamin C group) received nutritional therapy combined with doth of vitamin C (430 mg), while the third group (Vitamin E group) received nutritional therapy combined with high doth of vitamin E (50mg) Follow-up continued for 3month.
Results: There were significant improvement in ALT, AST, hemoglobin, glucose, weight, body mass index (BMI), muscles, fats, target Body Weight (TBW), Waist-Hip Ratio (WHR) and ultrasonography findings after treatment of NAFLD with vitamin E and C and the diet therapy in comparison with their value before treatment. In addition, there were highly statistically significant differences between both vitamin E and C and the diet therapy group.
Conclusion: Vitamin E and C as well as prescriptive diet therapy induced significant improvement in hepatic condition in NAFLD patients in terms of biochemical, anthropometric measurements and ultrasonography findings; however Vitamin E and C had more significant results compared to the nutritional therapy group.

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