Hepatoprotective activity and antioxidant effects of avocado peels (Persea americana) on rats hepatotoxicity induced by carbon tetrachloride.

Liver is the largest internal organ in human body. Avocado peels have effectively improved liver function and protect against liver tissues damage induced by carbon tetrachlorid. This study aimed to evaluate the impact of avocado peel to reduce hepatotoxicity in rats.Twenty four adult male ratsdivided into two main groups and fed on standard diet. Group I: negative control (6 rats). Group2:hepatotoxic groups (n=18), which were subjected to subcutaneous injection of a single dose of 0.3 ml/kg CC14 mixed with equal volume of corn oil on the 7th day. Hepatotoxic groups (n=18) were divided into (3)  subgroups 6 rats per group (1) positive control fed on basal diet, group (2) fed on basal diet containing 2.5% of avocado peel, group (3) fed on basal diet containing 5% of avocado peel powder. Food intake was calculated daily and rats were weighed weekly. Feeding and growth performance were carried out by the determination of food intake and body weight gain. At the end of experimental (30 day) injection administration of of a single dose of 0.3 ml/kg CC14 significantly increased levels of, liver function, , malonaldehyde, liver and kidney functions in positive control group. In contrast catalase and glutathione transferase were significantly decreased.Histopathological examination revealed degeneration of hepatocytes of rat livers treated with carbon tetrachlorid. Feeding rats with avocado peel at dose of 2.5 and 5%.  resulted in reducing levels of hepatotoxic in serum liver, malonaldehyde, liver and kidney functions compared to positive control group.The study concluded. Avocado peels have effectively improved liver function and protect against liver tissues damage induced by carbon tetrachloride inexperimental animals