Therapeutic Effect Of Isabgol And Sage On Obese Rats

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Obesity is considered as one important risk factor for many health problems. Salvia officinalis is proven to have benefit in cases of hypercholesterolemia, diabetes and obesity. Also, Plantago ovata is believed to have effects on many diseases that affect the body including obesity. This study aims to assess the effect of both Salvia officinalis and Plantago ovata on weight loss using obese rats with an evaluation of their effects on serum lipids, liver and kidney functions in different levels of concentration. Forty eight male albino rats weighing 150±2g were divided into eight groups and administered P. ovata and S. officinalis at different levels daily for 28 days. Blood samples were taken from each rat and centrifuged at 3000 rpm for 20 minutes. Serum was separated and stored at -20 degree C until biochemical estimations were carried out then the samples were analysed for HDL. LDL. VLDL , liver enzymes and kidney functions. Results showed that HDL-c levels were significantly increased in the treatment groups, while LDL-c levels were decreased significantly as compared to control positive. Liver enzymes (ALT and AST) were significantly decreased in all treatment groups compared to control positive. Also, concerning uric acid and urea nitrogen, the levels were reduced compared to control positive. Treating obese rats with different levels of P. ovata, S. officinalis and a mixture of them caused significant improvements in the biochemical measures and the best results  seems to be recorded for the mixture diet 7,5% P. ovata and S. officinalis are useful for obese patients regarding prevention of heart diseases and hardening of arteries

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