Amelioration of Hepatointoxication and Hyperglycemia by Diets Containing Herbs

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            This study was conducted to investigate the effect of Elder berry (Sambucus nigra ), Echinacea  (Echinacea purpurea) , Astragalus ( Astragalus hispidulus ) and Curry leaves (Murraya koenigii) plants on impaired liver function of injected rats with Carbon Chloride Tetra (Ccl4)   and    injected with Alloxan to induce hyper glycemia. Seventy eight mature albino rats weighting 150-160g B.Wt. each were used, and divided into 13 equal groups, one group was kept as a control –ve group , while the six groups were injected by (ccl4) once a day for a period of 4 days. The used plants in diets were : (Elderberry 5%, Echinacea 5% , Astragalus 5% , Curry leaves 5% , and as mixture of these plants 5%(1:1:1:1w/w) from the basal diet. And another six group were injected by Alloxan once a day  .The used plants in diets were : (Elderberry 5%, Echinacea 5% , Astragalus 5% , Curry leaves 5% , and as mixture of this plants 5% (1:1:1:1w/w) from the basal diet .Serum liver function (ALT,AST,ALP) CAT,SOD and GPX, kidney function (urea , creatinine , uric acid ),lipids profile( total cholesterol , triglycerides , lipoproteins "HDL , LDL , VLDL"),Gulcose and histopathological changes of  liver & kidney were examined .The obtained results concluding that the feeding with the tested plant parts improved the kidney functions , liver functions and lipid profile specially when a mixture of these studied herbs used.

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