Comparative Study for Group of Herbs VS. Glucophage Drug as Used for Obese Male Albino Rats

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This study aimed to examine the effect of Ispaghula husk, Bladder wrack, Senna Alexandrian horns and Cherry stem by 5 and 7% herbs powder as compared with effect of Glucophage drug for obese rats. Seventy two white male albino rats, weighting 160±5 g  were used in this study and divided into twelve groups, six rats each. One of them was kept as a control –ve group, while the other eleven groups were fed on high fat diet (10% fat in the form animal fat) to get obese rats. The herbs were added at percent 5,7% and 5% mixtune of them from the basel diet, and one of the group were fed on basal diet + glucophage drug( about 25mg/day being about 170mg/100g feed). At the end of the experiment, body weight, feed intake, feed efficiency ratio, serum glucose, serum liver enzymes activities (ALT, AST&  ALP), kidney function parameters (creatinine, uric acid& urea levels), serum lipid profiles (TG, TC, LDL-c, VLDL-c & HDL-c) were determined. The results of the obtained data indicated that tested plants significantly (P≤0.05) decreased body weight and decreased serum TC, TG, LDL, VLDL while increased HDL. Also, the tested plants improved liver and kidney functions. The obtained findings indicated that tested plant parts containing several compounds able to improve the adverse obesity side effects and decreased body weight. So, the data     recommended such plants by a moderate amount in our diets.
 

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